The Critical Coronavirus and Kids Epidemiology (CAKE) Study is a multinational study investigating the epidemiology and clinical course of severe and critical pediatric COVID-19. It is a collaboration of centers from multiple PICU research networks, including PALISI and LARed, plus centers from the Bronchiolitis and Co-Detection (BACON) Study.
We are enrolling children < 19 years old who have a positive test for SARS-CoV2 and are hospitalized for severe or critical COVID-19. Critical COVID-19 includes treatment with ICU-level respiratory support (high flow nasal cannula or invasive/noninvasive ventilation). Severe COVID- includes oxygen support less than critical but meeting the PALICC PARDS “at risk” threshold.
The study is collecting de-identified data, which includes a core data set as well as a brief daily data collection. All data will be entered into a secure online REDCap database hosted by Nationwide Children’s Hospital in Columbus, Ohio, USA. The database is currently available in English and Spanish, and we have plans to translate into Portuguese and French if there is enough interest. Each participating center is expected to get local ethics approval.
The goals of the study are to understand the epidemiology and clinical course of severe/critical COVID-19 including factors that may be associated with a severe presentation, initial presenting symptoms, laboratory findings, treatments, outcomes, and patient- or treatment-related factors that may be associated with improved (or worsened) outcomes. The CAKE study began on 1 April and is expected to run through the end of 2020. We currently have 60 centers from Europe, North America, and South America that are participating.
We continue to seek additional centers that would like to participate, especially from regions that are not currently represented in the study.
Please contact us either at BaconStudy@NationwideChildrens.org (English) or redcolaborativaucip@gmail.com (Spanish) for additional details.